High-Energy Phosphinylidyne Compounds

The project for the research and application of key technologies
for high-energy phosphinylidyne compounds completed by Nanjing
University of Technology has recently won the first prize of
Sinopec scientific and technological invention. Several
high-energy phosphinylidyne compounds in the project have
already achieved commercial production to produce drugs for
cardiovascular diseases. One derivative is a new compound and
a category of new drugs can hopefully be developed from the
compound in collaboration with producers.
   Many phosphinylidyne compounds are contained in organisms.
Great quantities of free energy can be released in the hydrolysis
of phosphate groups. Such substances are therefore called
high-energy phosphinylidyne compounds. They play an important
role in physiological activities. Through the research of
high-energy phosphinylidyne compounds new drugs for some
difficult and complicated diseases can hopefully be developed.
   In the project high-energy phosphinylidyne compounds are
effectively produced through the yeast whole-cell catalysis
technology by establishing metabolic network model, conducting
metabolic flow analysis and using chemical substances to control
metabolic flow and increase energy auto-linking efficiency.
Researchers have used a new technology to separate these
high-energy phosphinylidyne compounds and the yield can reach
98%. Besides, the resin consumption, the regenerant consumption
and the water consumption are greatly reduced, the product
concentration is increased by 20% - 40%, the energy consumption
is down by more than 70% and the cost is remarkably reduced.
    The research of high-energy phosphinylidyne compounds
conducted by Nanjing University of Technology and especially the
production of high-purity products conforming to the
international standards have bridged a gap in the research of
such compounds in China.